Kaye B R, Kaye R L, Bobrove A
Am J Med. 1984 Feb;76(2):279-92. doi: 10.1016/0002-9343(84)90787-3.
The literature relating to prevalence, characteristics, differential diagnosis, histologic features, pathogenesis, complications, and prognosis of rheumatoid nodules is tabulated and reviewed. The broad spectrum of conditions associated with rheumatoid nodules is discussed. A new classification of these clinical entities, reflecting disease characteristics and prognosis, is proposed. This classification is based on age, association or lack thereof with rheumatoid arthritis or rheumatic features, the presence or absence of rheumatoid factors, and the location of the rheumatoid nodules. Four cases of rheumatoid nodules in patients without rheumatoid factor are presented. Three patients had classic or definite rheumatoid arthritis, and one had palindromic rheumatism. In follow-ups lasting one to 15 years, significant permanent joint deformities, bony erosions, or extra-articular manifestations of rheumatoid arthritis have not developed in any of the patients. All have experienced significant periods of remission.
本文将与类风湿结节的患病率、特征、鉴别诊断、组织学特征、发病机制、并发症及预后相关的文献制成表格并进行综述。讨论了与类风湿结节相关的广泛病症。提出了一种反映疾病特征和预后的这些临床实体的新分类方法。该分类基于年龄、与类风湿关节炎或风湿特征的关联与否、类风湿因子的有无以及类风湿结节的位置。报告了4例无类风湿因子患者的类风湿结节病例。3例患者患有典型或明确的类风湿关节炎，1例患有回纹型风湿症。在长达1至15年的随访中，所有患者均未出现类风湿关节炎的显著永久性关节畸形、骨质侵蚀或关节外表现。所有患者均经历了显著的缓解期。
