Philipps A F, Matty P J, Porte P J, Raye J R
Am J Obstet Gynecol. 1984 Feb 15;148(4):481-7. doi: 10.1016/0002-9378(84)90730-0.
The modulation of fetal insulin secretion by prostaglandins was studied with the aid of the prostaglandin synthesis inhibitors indomethacin and sodium salicylate in 10 chronically catheterized fetal lambs. Glucose-induced fetal insulin secretion was inhibited within 60 minutes by preinjection of either indomethacin or sodium salicylate in the fetal lambs. In the sodium salicylate experiments a significant (p less than 0.01) dose-related response (degree of insulin suppression) was noted between doses of 100 to 350 mg/kg of fetal weight. In a selected group of sodium salicylate injections prostaglandin levels were found to fall to 58% of control by 2 hours after injection. Five neonatal lambs exposed to a similar regimen were noted to have an exaggerated insulin response to glucose infusion when compared to fetal lambs. However, indomethacin or sodium salicylate pretreatment resulted in no suppression of glucose-induced insulin release. This finding may be of importance in explaining the observation of an increased incidence of fetal growth retardation after long-term exposure to salicylates in humans and in animal models.
借助前列腺素合成抑制剂吲哚美辛和水杨酸钠，在10只长期插管的胎羊中研究了前列腺素对胎儿胰岛素分泌的调节作用。在胎羊中，预先注射吲哚美辛或水杨酸钠可在60分钟内抑制葡萄糖诱导的胎儿胰岛素分泌。在水杨酸钠实验中，在100至350毫克/千克胎儿体重的剂量之间观察到显著的（p小于0.01）剂量相关反应（胰岛素抑制程度）。在一组选定的水杨酸钠注射实验中，发现注射后2小时前列腺素水平降至对照的58%。与胎羊相比，5只接受类似方案的新生羔羊对葡萄糖输注的胰岛素反应过度。然而，吲哚美辛或水杨酸钠预处理并未抑制葡萄糖诱导的胰岛素释放。这一发现对于解释在人类和动物模型中长期接触水杨酸盐后胎儿生长迟缓发生率增加的观察结果可能具有重要意义。
