Chen M, Robertson R P
Prostaglandins. 1979 Oct;18(4):557-67. doi: 10.1016/0090-6980(79)90023-6.
Prostaglandin E (PGE) has been hypothesized to be an endogenous regulator of carbohydrate metabolism because it decreases human insulin secretion and carbohydrate tolerance. This report compares the effects of four inhibitors of PGE synthesis on the acute insulin response to glucose and subsequent glucose disappearance rates. Ibuprofen, acetylsalicylic acid and sodium salicylate treatments in normal volunteers were associated with augmented insulin secretion and improved glucose tolerance while indomethacin had the opposite effects. In view of these findings and the known effects of PGE on carbohydrate metabolism, we suggest that the effects of indomethacin may have been due to an action of the drug other than inhibiting PGE synthesis.
前列腺素E（PGE）被认为是碳水化合物代谢的内源性调节剂，因为它会降低人体胰岛素分泌和碳水化合物耐量。本报告比较了四种PGE合成抑制剂对葡萄糖急性胰岛素反应及随后葡萄糖消失率的影响。正常志愿者使用布洛芬、乙酰水杨酸和水杨酸钠治疗后，胰岛素分泌增加，葡萄糖耐量改善，而吲哚美辛则产生相反的效果。鉴于这些发现以及PGE对碳水化合物代谢的已知作用，我们认为吲哚美辛的作用可能是由于该药物的某种作用，而非抑制PGE合成。
