Hellman S, Reincke U, Botnick L, Mauch P
J Clin Oncol. 1983 Apr;1(4):277-84. doi: 10.1200/JCO.1983.1.4.277.
Recent discoveries indicate that hematopoietic stem cells have limits on their proliferative capacity and are unable to divide indefinitely. There is great heterogeneity within the compartment as to the extent of this proliferative limitation. At any given time it appears that hematopoiesis is maintained by the progeny of only a few stem cells. When these are exhausted the progeny from other stem cells take their place. The observations of proliferative limitation, heterogeneity, and clonal succession must be incorporated into any model of stem cell organization. These new discoveries and the models incorporating them have important clinical implications. They may explain the inability of normal tissues to develop drug resistance and they also offer a mechanism by which cell renewal systems decrease the development of malignancies. In the selection of chemotherapeutic agents not only the effectiveness of the drug upon the tumor must be considered, but also how specific agents affect the stem cell compartment. These data have important implications in the use of bone marrow transplantation for both malignant and nonmalignant disease.
最近的发现表明，造血干细胞的增殖能力有限，无法无限期分裂。在这个细胞区室内，这种增殖限制的程度存在很大的异质性。在任何给定时间，造血似乎仅由少数干细胞的后代维持。当这些干细胞耗尽时，其他干细胞的后代会取而代之。增殖限制、异质性和克隆更替的观察结果必须纳入任何干细胞组织模型中。这些新发现以及包含它们的模型具有重要的临床意义。它们可能解释了正常组织无法产生耐药性的原因，并且还提供了一种细胞更新系统减少恶性肿瘤发生的机制。在选择化疗药物时，不仅要考虑药物对肿瘤的有效性，还要考虑特定药物如何影响干细胞区室。这些数据对于恶性和非恶性疾病的骨髓移植应用具有重要意义。
