Gollaher C J, Wood R J, Holl M, Allen L H
J Nutr. 1984 Mar;114(3):622-6. doi: 10.1093/jn/114.3.622.
In previous studies we have demonstrated that the reduced renal reabsorption of calcium and hypercalciuria resulting from protein consumption are associated with serum insulin levels. Arginine stimulation of insulin secretion also results in hypercalciuria. The present study was designed to test whether the calciuria associated with arginine-stimulated insulin secretion is mediated by insulin inhibition of parathyroid hormone (PTH) activity. Parathyroidectomized (PTX) and sham-operated rats were infused with physiological saline, or with 12 mmol X kg-1 X hour-1 arginine in saline at 1.2 ml/hour. Analysis of data from clearance periods 90-150 minutes after infusions commenced show that arginine infusion increased urine volume, and calcium excretion (nanograms/minute and nanograms/milliliter glomerular filtration rate), to the same extent in PTX and sham-operated animals. PTH does not, therefore, appear to be involved in the calciuretic response to amino acid infusion.
在先前的研究中，我们已经证明，蛋白质摄入导致的肾脏钙重吸收减少和高钙尿症与血清胰岛素水平有关。精氨酸刺激胰岛素分泌也会导致高钙尿症。本研究旨在测试与精氨酸刺激胰岛素分泌相关的钙尿症是否由胰岛素对甲状旁腺激素（PTH）活性的抑制介导。对甲状旁腺切除（PTX）和假手术大鼠以1.2毫升/小时的速度输注生理盐水，或以12毫摩尔/千克/小时的精氨酸溶于生理盐水中进行输注。对输注开始后90 - 150分钟清除期的数据分析表明，在PTX和假手术动物中，精氨酸输注使尿量和钙排泄量（纳克/分钟和纳克/毫升肾小球滤过率）增加到相同程度。因此，PTH似乎不参与对氨基酸输注的钙尿反应。
