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1
Synthetic somatomedin C: comparison with natural hormone isolated from human plasma.合成生长调节素C：与从人血浆中分离出的天然激素的比较。
Proc Natl Acad Sci U S A. 1984 Feb;81(3):740-2. doi: 10.1073/pnas.81.3.740.
2
Inhibition of the mitogenic effects of plasma by a monoclonal antibody to somatomedin C.用生长调节素C单克隆抗体抑制血浆的促有丝分裂作用。
Proc Natl Acad Sci U S A. 1984 Apr;81(8):2389-92. doi: 10.1073/pnas.81.8.2389.
3
Purification of somatomedin-C from human plasma: chemical and biological properties, partial sequence analysis, and relationship to other somatomedins.从人血浆中纯化生长调节素-C：化学和生物学特性、部分序列分析及其与其他生长调节素的关系。
Biochemistry. 1980 Feb 19;19(4):790-7. doi: 10.1021/bi00545a027.
4
Differential effects of epidermal growth factor, somatomedin-C/insulin-like growth factor I, and transforming growth factor-beta on porcine granulosa cell deoxyribonucleic acid synthesis and cell proliferation.表皮生长因子、生长调节素-C/胰岛素样生长因子I以及转化生长因子-β对猪颗粒细胞脱氧核糖核酸合成及细胞增殖的不同作用
Endocrinology. 1988 Jul;123(1):168-79. doi: 10.1210/endo-123-1-168.
5
Somatomedin-C and platelet-derived growth factor stimulate human fibroblast replication.生长调节素C和血小板衍生生长因子刺激人成纤维细胞复制。
J Cell Physiol. 1981 Mar;106(3):361-7. doi: 10.1002/jcp.1041060305.
6
Expression of a biologically active analogue of somatomedin-C/insulin-like growth factor I.生长调节素-C/胰岛素样生长因子I生物活性类似物的表达
Gene. 1985;35(1-2):83-9. doi: 10.1016/0378-1119(85)90160-x.
7
Total synthesis of insulin-like growth factor I (somatomedin C).胰岛素样生长因子I（生长调节素C）的全合成。
Proc Natl Acad Sci U S A. 1983 Apr;80(8):2216-20. doi: 10.1073/pnas.80.8.2216.
8
Effects of platelet-derived growth factor and somatomedin-C/insulin-like growth factor I on the deoxyribonucleic acid replication of fetal rat islets of Langerhans in tissue culture.
Endocrinology. 1988 Jan;122(1):214-8. doi: 10.1210/endo-122-1-214.
9
Regulation of DNA synthesis in human fetal hepatocytes by placental lactogen, growth hormone, and insulin-like growth factor I/somatomedin-C.胎盘催乳素、生长激素及胰岛素样生长因子I/生长调节素-C对人胎儿肝细胞DNA合成的调控
J Cell Physiol. 1987 Jul;132(1):33-40. doi: 10.1002/jcp.1041320105.
10
Comparison of [125I]somatomedin A and [125I]somatomedin C radioreceptor assays for somatomedin peptide content in whole and acid-chromatographed plasma.
J Clin Endocrinol Metab. 1978 Dec;47(6):1287-95. doi: 10.1210/jcem-47-6-1287.

引用本文的文献

1
Chemical synthesis of a gene for somatomedin C.生长调节素C基因的化学合成
Nucleic Acids Res. 1985 Apr 25;13(8):2959-77. doi: 10.1093/nar/13.8.2959.
2
Human recombinant insulin-like growth factor I. II. Binding characterization and radioreceptor assay development using Balb/c 3T3 mouse embryo fibroblasts.人重组胰岛素样生长因子I. II. 使用Balb/c 3T3小鼠胚胎成纤维细胞的结合特性及放射受体分析方法的建立
In Vitro Cell Dev Biol. 1988 Nov;24(11):1107-13. doi: 10.1007/BF02620812.

本文引用的文献

1
Evidence that somatomedin is synthesized by multiple tissues in the fetus.有证据表明，生长调节素是由胎儿的多种组织合成的。
Dev Biol. 1980 Mar 15;75(2):315-28. doi: 10.1016/0012-1606(80)90166-9.
2
Purification of somatomedin-C from human plasma: chemical and biological properties, partial sequence analysis, and relationship to other somatomedins.从人血浆中纯化生长调节素-C：化学和生物学特性、部分序列分析及其与其他生长调节素的关系。
Biochemistry. 1980 Feb 19;19(4):790-7. doi: 10.1021/bi00545a027.
3
Insulin-like growth factor I stimulates growth in hypophysectomized rats.胰岛素样生长因子I刺激垂体切除大鼠的生长。
Nature. 1982 Mar 18;296(5854):252-3. doi: 10.1038/296252a0.
4
[Somatomedin inhibition of the growth hormone secretion stimulated by the hypothalamic factor somatocrinin or the synthetic peptide hpGRF].[生长调节素对由下丘脑因子生长激素释放素或合成肽hpGRF刺激的生长激素分泌的抑制作用]
C R Seances Acad Sci III. 1982 Nov 29;295(11):651-4.
5
Epidermal growth factor (EGF) and somatomedin C regulate G1 progression in competent BALB/c-3T3 cells.表皮生长因子（EGF）和生长调节素C调节有能力的BALB/c - 3T3细胞中的G1期进程。
Exp Cell Res. 1982 Sep;141(1):107-15. doi: 10.1016/0014-4827(82)90073-8.
6
Human growth hormone and somatomedin C suppress the spontaneous release of growth hormone in unanesthetized rats.人类生长激素和生长调节素C可抑制未麻醉大鼠生长激素的自发释放。
Endocrinology. 1983 Oct;113(4):1319-24. doi: 10.1210/endo-113-4-1319.
7
Total synthesis of insulin-like growth factor I (somatomedin C).胰岛素样生长因子I（生长调节素C）的全合成。
Proc Natl Acad Sci U S A. 1983 Apr;80(8):2216-20. doi: 10.1073/pnas.80.8.2216.
8
Hormonal control of immunoreactive somatomedin production by cultured human fibroblasts.培养的人成纤维细胞产生免疫反应性生长调节素的激素控制
J Clin Invest. 1981 Jan;67(1):10-9. doi: 10.1172/JCI110001.
9
Sequence analysis of somatomedin-C: confirmation of identity with insulin-like growth factor I.生长调节素-C的序列分析：与胰岛素样生长因子I一致性的确证
Endocrinology. 1983 Jun;112(6):2215-7. doi: 10.1210/endo-112-6-2215.
10
Insulin-like growth factors: a role in growth hormone negative feedback and body weight regulation via brain.胰岛素样生长因子：通过大脑在生长激素负反馈和体重调节中的作用。
Science. 1983 Apr 1;220(4592):77-9. doi: 10.1126/science.6338593.

合成生长调节素C：与从人血浆中分离出的天然激素的比较。

Synthetic somatomedin C: comparison with natural hormone isolated from human plasma.

作者信息

Van Wyk J J, Russell W E, Li C H

出版信息

Proc Natl Acad Sci U S A. 1984 Feb;81(3):740-2. doi: 10.1073/pnas.81.3.740.

DOI:10.1073/pnas.81.3.740
PMID:6366789
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC344911/
Abstract

The biological and immunological properties of a chemically synthesized preparation of somatomedin C (Sm-C) were compared with those of the natural product isolated from human plasma. The two preparations produced identical curves in the radioimmunoassay and radioreceptor assay for Sm-C and in the radioreceptor assay for insulin. They were identical in their ability to stimulate DNA synthesis in confluent BALB/c 3T3 cells previously exposed to platelet-derived growth factor, and the biological activities of both preparations were completely neutralized by a monoclonal antibody raised against native Sm-C. These studies demonstrate that the chemically synthesized product is equivalent to the native molecule in all important respects and that it can be used interchangeably with the natural product for any studies that are contemplated.

摘要

将化学合成的生长调节素C（Sm-C）制剂的生物学和免疫学特性与从人血浆中分离出的天然产物的特性进行了比较。这两种制剂在Sm-C的放射免疫测定和放射受体测定以及胰岛素的放射受体测定中产生了相同的曲线。它们在刺激先前暴露于血小板衍生生长因子的汇合BALB/c 3T3细胞中DNA合成的能力方面是相同的，并且两种制剂的生物活性都被针对天然Sm-C产生的单克隆抗体完全中和。这些研究表明，化学合成产物在所有重要方面都等同于天然分子，并且在任何预期的研究中都可以与天然产物互换使用。