O'Brien K D, Hackman R C, Sale G E, Prentice R, Deeg J, Thomas E D, Storb R
Transplantation. 1984 Mar;37(3):233-8. doi: 10.1097/00007890-198403000-00003.
We reviewed coded autopsy material from 71 dogs, 46 receiving allogeneic and 25 receiving autologous bone marrow transplants, to evaluate the hypothesis that lymphocytic bronchitis is associated with severe acute graft-versus-host disease (GVHD). We found no significant correlation between the presence of lymphocytic bronchitis and severe acute GVHD (P greater than 0.16). Using a binary regression model that corrected for possible confounding relationships, we failed to show a correlation between lymphocytic bronchitis and acute GVHD of each of the 3 classically affected organ systems. Also, no correlation was found between lymphocytic bronchitis and acute bacterial pneumonia (P greater than 0.32). Finally, lymphocytic bronchitis was present in autografted dogs with a prevalence at autopsy not significantly different from that of allografted dogs (P greater than 0.32). We conclude that lymphocytic bronchitis in this canine model represents nonspecific inflammation rather than acute pulmonary GVHD.
我们回顾了71只犬的编码尸检材料，其中46只接受了同种异体骨髓移植，25只接受了自体骨髓移植，以评估淋巴细胞性支气管炎与严重急性移植物抗宿主病（GVHD）相关的假说。我们发现淋巴细胞性支气管炎的存在与严重急性GVHD之间无显著相关性（P大于0.16）。使用校正了可能混杂关系的二元回归模型，我们未能显示淋巴细胞性支气管炎与3个经典受累器官系统中每个系统的急性GVHD之间存在相关性。此外，未发现淋巴细胞性支气管炎与急性细菌性肺炎之间存在相关性（P大于0.32）。最后，自体移植犬出现淋巴细胞性支气管炎，尸检时的患病率与同种异体移植犬无显著差异（P大于0.32）。我们得出结论，在这个犬模型中，淋巴细胞性支气管炎代表非特异性炎症而非急性肺部GVHD。
