Taube D H, Welsh K I, Kennedy L A, Thick M G, Bewick M, Cameron J S, Ogg C S, Rudge C J, Williams D G
Transplantation. 1984 Mar;37(3):254-5. doi: 10.1097/00007890-198403000-00007.
The successful removal and prevention of the resynthesis of an anti-HLA antibody by plasma exchange and immunosuppression in a patient awaiting renal transplantation is described. Before treatment, the patient's serum contained a high titer (greater than 1/50) anti-HLA antibody that reacted with 94% of our lymphocyte donor panel and produced positive cross matches with the lymphocytes from 40 cadaver kidneys. Following treatment, her anti-HLA titers fell to less than 1/10 and her sera reacted with 43% of our lymphocyte donor panel and produced negative crossmatches with lymphocytes from the first two cadaver kidney donors she was tested against. She was successfully transplanted with the second of these kidneys and is now well eight months later, with good graft function.
本文描述了一名等待肾移植患者通过血浆置换和免疫抑制成功清除抗 HLA 抗体并防止其重新合成的病例。治疗前，患者血清中含有高滴度（大于 1/50）的抗 HLA 抗体，该抗体与我们 94% 的淋巴细胞供者库发生反应，并与 40 个尸体肾的淋巴细胞产生阳性交叉配型。治疗后，她的抗 HLA 滴度降至小于 1/10，其血清与我们 43% 的淋巴细胞供者库发生反应，并与她接受检测的前两个尸体肾供者的淋巴细胞产生阴性交叉配型。她成功移植了第二个这样的肾脏，八个月后情况良好，移植肾功能正常。
