Neild G H, Reuben R, Hartley R B, Cameron J S
J Clin Pathol. 1985 Mar;38(3):253-8. doi: 10.1136/jcp.38.3.253.
We have found glomerular capillary thrombi or afferent arteriolar thrombosis in eight renal biopsy specimens from seven renal allograft recipients. All patients were receiving cyclosporin and prednisolone. Biopsies were performed either routinely one and four weeks after transplantation or during periods of renal dysfunction. None of the patients whose biopsy material contained glomerular thrombi was considered, in retrospect, to have been undergoing rejection at the time of biopsy. Thrombi consisted of finely granular material partially obstructing glomerular capillaries. By light microscopy the staining characteristics of the thrombi were compatible with platelet-fibrin aggregates, and this was confirmed by immunoperoxidase examination. Such thrombi have not previously been seen in biopsy material from patients treated with prednisolone and azathioprine, except rarely associated with acute vascular injection. In none of these patients was there haematological evidence of the haemolytic uraemic syndrome as has been reported in bone marrow recipients treated with cyclosporin.
我们在7例肾移植受者的8份肾活检标本中发现了肾小球毛细血管血栓形成或入球小动脉血栓形成。所有患者均接受环孢素和泼尼松龙治疗。活检在移植后1周和4周常规进行，或在肾功能不全期间进行。回顾性分析发现，活检材料中含有肾小球血栓的患者在活检时均未发生排斥反应。血栓由部分阻塞肾小球毛细血管的细颗粒物质组成。光镜下，血栓的染色特征与血小板 - 纤维蛋白聚集体相符，免疫过氧化物酶检查证实了这一点。除了很少与急性血管内注射相关外，以前在用泼尼松龙和硫唑嘌呤治疗的患者的活检材料中未见此类血栓。这些患者均无溶血尿毒综合征的血液学证据，而在用环孢素治疗的骨髓移植受者中曾有过相关报道。
