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未过滤自体骨髓移植后的肺骨髓栓塞

Pulmonary bone-marrow embolisation after unfiltered autologous bone-marrow transplantation.

作者信息

Alvegård T A, Berg N O, Willén H

出版信息

Acta Pathol Microbiol Immunol Scand A. 1984 Jan;92(1):81-2. doi: 10.1111/j.1699-0463.1984.tb04381.x.

DOI:10.1111/j.1699-0463.1984.tb04381.x
PMID:6367358
Abstract

A 15-year-old girl had Ewing's sarcoma of the right scapula 1978 and was treated with local radiotherapy and adjuvant chemotherapy. She remained in complete remission until September 1982 when she developed a single pulmonary metastasis in the right lower lobe. She received a high dose of Melphalan twice, always followed by autologous bone-marrow transplantation. A segmental right lower lobectomy revealed haematopoietic bone-marrow tissue emboli within the alveolar capillaries and foreign body granulomatous lesions in the whole surgical specimen. No residual Ewing's sarcoma growth was seen.

摘要

一名15岁女孩于1978年患右肩胛骨尤因肉瘤,接受了局部放疗和辅助化疗。她一直处于完全缓解状态,直到1982年9月,她右肺下叶出现单个肺转移灶。她接受了两次大剂量美法仑治疗,每次治疗后均进行自体骨髓移植。右下叶节段性切除术后,在肺泡毛细血管内发现造血骨髓组织栓子,整个手术标本中有异物肉芽肿性病变。未见尤因肉瘤残留生长。

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1
Pulmonary bone-marrow embolisation after unfiltered autologous bone-marrow transplantation.未过滤自体骨髓移植后的肺骨髓栓塞
Acta Pathol Microbiol Immunol Scand A. 1984 Jan;92(1):81-2. doi: 10.1111/j.1699-0463.1984.tb04381.x.
2
High dose melphalan with autologous bone marrow transplantation in the treatment of metastatic Ewing's sarcoma.大剂量美法仑联合自体骨髓移植治疗转移性尤因肉瘤。
Ir J Med Sci. 1983 Apr;152(4):160-4. doi: 10.1007/BF02960061.
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High-dose melphalan, etoposide, total-body irradiation, and autologous stem-cell reconstitution as consolidation therapy for high-risk Ewing's sarcoma does not improve prognosis.大剂量美法仑、依托泊苷、全身照射及自体干细胞重建作为高危尤因肉瘤的巩固治疗并不能改善预后。
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Magna-field irradiation and autologous marrow rescue in the tratment of pediatric solid tumors.磁场照射与自体骨髓挽救疗法治疗小儿实体瘤
Int J Radiat Oncol Biol Phys. 1983 Dec;9(12):1951-4. doi: 10.1016/0360-3016(83)90367-x.
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High-dose induction chemoradiotherapy followed by autologous bone marrow transplantation as consolidation therapy in rhabdomyosarcoma, extraosseous Ewing's sarcoma, and undifferentiated sarcoma.大剂量诱导放化疗后行自体骨髓移植作为横纹肌肉瘤、骨外尤文肉瘤和未分化肉瘤的巩固治疗。
J Clin Oncol. 1998 May;16(5):1697-706. doi: 10.1200/JCO.1998.16.5.1697.
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Therapy-related chronic myelogenous leukaemia following autologous stem cell transplantation for Ewing's sarcoma.尤因肉瘤自体干细胞移植后发生的治疗相关慢性粒细胞白血病。
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Intensive combined modality therapy including low-dose TBI in high-risk Ewing's Sarcoma Patients.强化联合治疗模式,包括对高危尤因肉瘤患者采用低剂量全身照射。
Int J Radiat Oncol Biol Phys. 1983 Dec;9(12):1955-60. doi: 10.1016/0360-3016(83)90368-1.
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High-risk Ewing's sarcoma: end-intensification using autologous bone marrow transplantation.高危尤因肉瘤:采用自体骨髓移植进行强化治疗。
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High-dose chemotherapy and autologous peripheral blood stem-cell transfusion after conventional chemotherapy for patients with high-risk Ewing's tumors.高危尤因肉瘤患者在接受常规化疗后进行大剂量化疗及自体外周血干细胞输注。
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Bone marrow involvement identifies a subgroup of advanced Ewing sarcoma patients with fatal outcome irrespective of therapy in contrast to curable patients with multiple bone metastases but unaffected marrow.骨髓受累可确定一组晚期尤因肉瘤患者,无论接受何种治疗,其预后均不佳,这与可治愈的多骨转移但骨髓未受累的患者形成对比。
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引用本文的文献

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Ewing's sarcoma in scapula, epidemiology, clinical manifestation, diagnosis and treatment: A literature review.肩胛骨尤因肉瘤的流行病学、临床表现、诊断与治疗:文献综述
Ann Med Surg (Lond). 2022 Apr 11;77:103617. doi: 10.1016/j.amsu.2022.103617. eCollection 2022 May.
2
CT demonstration of asymptomatic pulmonary emboli after bone marrow transplantation: case report.骨髓移植后无症状肺栓塞的CT表现:病例报告
Pediatr Radiol. 1987;17(1):65-7. doi: 10.1007/BF02386599.