Feltis J T, Churg J, Holley K M, Feiner H, Gallo G, Ackad A S
Am J Kidney Dis. 1984 Mar;3(5):349-56. doi: 10.1016/s0272-6386(84)80082-7.
Berger's disease, or IgA nephropathy, is generally considered as pursuing a chronic course, often with recurrent attacks of gross hematuria or persistent microscopic hematuria. However, little attention has been paid to the acute changes that may accompany this nephropathy, and there are few reports of follow-up renal biopsy studies in these patients. We have had the opportunity to study two patients with Berger's disease (IgA nephropathy) in whom initial and follow-up renal biopsy studies were available. Both of these patients presented clinically with gross hematuria and moderately heavy proteinuria. In both cases, the initial renal biopsy disclosed diffuse mesangial proliferation associated with crescent formation, while follow-up biopsy disclosed only mild mesangial proliferation and no crescents. In one case electron microscopy revealed prominent subendothelial and small mesangial deposits in the initial biopsy, which became almost solely large mesangial in the second biopsy. The other case demonstrated only mesangial deposits in both biopsies.
伯杰氏病，即IgA肾病，通常被认为病程呈慢性，常伴有肉眼血尿反复发作或持续性镜下血尿。然而，对于这种肾病可能伴随的急性变化关注甚少，关于这些患者的随访肾活检研究报告也很少。我们有机会研究两名患有伯杰氏病（IgA肾病）的患者，他们有初始和随访肾活检研究资料。这两名患者临床上均表现为肉眼血尿和中度蛋白尿。在这两个病例中，初始肾活检显示弥漫性系膜增生伴新月体形成，而随访活检仅显示轻度系膜增生且无新月体。在一个病例中，电子显微镜检查显示初始活检中有明显的内皮下和小系膜沉积物，而在第二次活检中几乎仅为大系膜沉积物。另一例在两次活检中均仅显示系膜沉积物。
