Ultrastructure of acute glomerular injury in IgA nephritis.

In the ultrastructure of an acute glomerular injury in two cases of IgA nephritis (Berger's disease), the tissue damage was characterized by intravascular coagulation and an influx of fibrin-like materials into the Bowman's space forming focal and local exudative disorganizing lesion. It is supposed that this lesion correlates with the segmental fibrinoid necrosis of light microscopic expression and could be the initial event resulting in small crescents and/or local adhesive lesions of IgA nephritis.