Adams M M, Weis P, Oakley G P, Falek A
Am J Obstet Gynecol. 1984 Mar 15;148(6):749-51. doi: 10.1016/0002-9378(84)90560-x.
A follow-up was made of the parents of a population-based cohort of 154 infants with spina bifida who were born in Atlanta during 1972-1979. We interviewed the parents of these infants and, for pregnancies after the spina bifida-affected birth, the ratio of use of prenatal diagnosis and the rate of recurrence of spina bifida were ascertained. Among 43 pregnancies which occurred in 1976 or later, and which occurred after a spina bifida-affected birth, prenatal diagnosis was used for 27 pregnancies (63%). For whites, among full siblings born after a spina bifida-affected birth, the recurrence rate for spina bifida was 2% (1/51). For blacks, among seven full siblings born after a spina bifida-affected birth, none was affected. Prenatal diagnosis appears to be well accepted among these parents of infants with spina bifida.
对1972年至1979年在亚特兰大出生的154名脊柱裂婴儿的基于人群队列的父母进行了随访。我们采访了这些婴儿的父母，并确定了脊柱裂患儿出生后怀孕时的产前诊断使用率和脊柱裂复发率。在1976年或之后发生的、脊柱裂患儿出生后的43次怀孕中，27次怀孕（63%）进行了产前诊断。对于白人，在脊柱裂患儿出生后的全同胞中，脊柱裂的复发率为2%（1/51）。对于黑人，在脊柱裂患儿出生后的7名全同胞中，无人患病。产前诊断在这些脊柱裂婴儿的父母中似乎得到了很好的接受。
