Wicomb W N, Cooper D K, Novitzky D, Barnard C N
Ann Thorac Surg. 1984 Mar;37(3):243-8. doi: 10.1016/s0003-4975(10)60333-5.
Four patients have undergone heterotopic heart transplantation with donor hearts stored by a portable hypothermic perfusion system. Total ischemic periods ranged from 6 hours 55 minutes to 16 hours 50 minutes. One heart, transplanted into a patient who had acutely rejected a previous graft, suffered accelerated, irreversible, acute rejection within five days, associated with strong antibody formation; donor heart function was never good. In the 3 remaining patients, donor heart function was good after initially being poor for a few hours in 2 patients. One patient died of long-term rejection after 6 months and 1 of tuberculous meningitis after 10 months; 1 remains alive at 15 months. Neither preservation of the donor heart for periods in excess of approximately 4 hours nor the use of continuous hypothermic perfusion as a method of preservation appears to have been reported previously in the context of the clinical situation.
4例患者接受了采用便携式低温灌注系统保存供心的异位心脏移植。总的缺血时间为6小时55分钟至16小时50分钟。1例心脏移植给1名曾急性排斥过先前移植心脏的患者，该心脏在5天内发生加速性、不可逆的急性排斥反应，伴有强效抗体形成；供心功能一直不佳。在其余3例患者中，2例患者的供心最初几小时功能较差，但随后功能良好。1例患者在6个月后死于长期排斥反应，1例在10个月后死于结核性脑膜炎；1例在15个月时仍存活。在这种临床情况下，此前似乎尚未有关于供心保存时间超过约4小时或使用持续低温灌注作为保存方法的报道。
