Snider D E, Powell K E
Arch Intern Med. 1984 Mar;144(3):589-90.
Most of the commonly used antituberculosis drugs are excreted in the breast milk of nursing mothers. However, only a small fraction of the adult dose appears in breast milk, and we estimate that breast-fed infants would receive no more than 20% of the usual therapeutic dose for infants for any of these drugs. Based on these considerations, we believe the risk of toxic reactions to drugs in infants of nursing mothers receiving antituberculosis drugs is very low. Nevertheless, the decision to breast-feed while taking antituberculosis drugs must be an individual one that takes into account the known facts, professional opinion, and the patient's values and preferences.
大多数常用的抗结核药物会通过哺乳期母亲的乳汁排出。然而，母乳中出现的成人剂量仅为一小部分，并且我们估计，母乳喂养的婴儿从母乳中获得的这些药物中的任何一种都不会超过婴儿通常治疗剂量的20%。基于这些考虑，我们认为接受抗结核药物治疗的哺乳期母亲所哺育婴儿出现药物毒性反应的风险非常低。尽管如此，在服用抗结核药物期间是否进行母乳喂养的决定必须因人而异，要考虑到已知事实、专业意见以及患者的价值观和偏好。
