Crivii S M, Crişan M, Crişan M
Arch Geschwulstforsch. 1984;54(1):85-9.
Leukocyte migration inhibition factor (LMIF) activity expressed as a migration index was studied in sera of 13 chronic lymphatic leukemia (CLL) patients and 14 healthy subjects. LMIF activity was present in 92.8% of CLL patients and 14% of controls. The LMIF activity of lymphocyte culture supernatants in the same patients and 7 controls was also studied. A LMIF-like activity was found both, in the sera and phytohemagglutinin (PHA) unstimulated cell supernatants in 9 of 13 patients (69.2%). These results demonstrate the ability of malignant B cells to release LMIF or LMIF-like factors spontaneously.
以迁移指数表示的白细胞迁移抑制因子（LMIF）活性在13例慢性淋巴细胞白血病（CLL）患者和14名健康受试者的血清中进行了研究。92.8%的CLL患者和14%的对照者存在LMIF活性。对相同患者和7名对照者的淋巴细胞培养上清液中的LMIF活性也进行了研究。在13例患者中的9例（69.2%）的血清和植物血凝素（PHA）未刺激的细胞上清液中均发现了类似LMIF的活性。这些结果证明了恶性B细胞自发释放LMIF或LMIF样因子的能力。
