Spontaneous production of lymphocyte migration inhibitory factor (sLyMIF) by T and B lymphocytes from peripheral rabbit blood.

Nonstimulated 24 h cultures of lymphocytes from rabbit peripheral blood, as well as isolated rabbit T and B lymphocytes release into the culture medium a factor inhibiting migration of T and B lymphocytes (LyMIF). Synthesis of the factor can be blocked by puromycin. The stimulatory factor for B lymphocyte migration (LyMSF) can also be produced in T lymphocyte cultures. The synthesis of both factors occurs in suspensions containing monocytes, as well as in those lacking monocytes.