Ahlgren F I
Acta Anaesthesiol Scand. 1978;22(1):93-7. doi: 10.1111/j.1399-6576.1978.tb01285.x.
The effects of halothane anesthesia on coronary circulation and cardiac work were studied in normovolemic and hypovolemic dogs, with aid of the radioactive microsphere technique. During normovolemia, halothane depressed the heart rate, cardiac output, arterial mean blood pressure and left ventricular work, with a simultaneous decrease in the coronary blood flow. During moderate hypovolemia, the arterial blood pressure was reduced as well as the coronary blood flow; whereas during hemorrhagic hypotension (severe hypovolemia), the arterial blood pressure was slightly increased and the coronary blood flow was unchanged with a reduced heart rate and increased stroke volume.
借助放射性微球技术，在血容量正常和血容量减少的犬身上研究了氟烷麻醉对冠脉循环和心脏作功的影响。在血容量正常时，氟烷使心率、心输出量、动脉平均血压和左心室作功降低，同时冠脉血流量减少。在中度血容量减少时，动脉血压和冠脉血流量均降低；而在出血性低血压（严重血容量减少）时，动脉血压略有升高，冠脉血流量不变，心率降低，每搏量增加。
