Grover F L, Webb G E, Bevis V, Fewel J G
Ann Thorac Surg. 1976 Nov;22(5):429-35. doi: 10.1016/s0003-4975(10)64451-7.
This study was undertaken to determine the relative effects of morphine and halothane anesthesia on coronary blood flow. Right heart bypass was instituted in 20 dogs by draining the vena cava blood into a cardiotomy reservoir and returning it to the main pulmonary artery. Coronary sinus drainage was measured by a right ventricular cannula. Group I (10 dogs) was sequentially given 0.5, 1, 1.5, 2.0, and 2.5% halothane. Group II (10 dogs) was given 1, 2, 3, 4, and 5 mg per kilogram of morphine intravenously. Arterial pressure, coronary sinus blood flow, cardiac output, arterial pH, PCO2, and PO2 were determined and repeated at each dose level of anesthesia and compared to the control values. Morphine significantly increased coronary flow at 3, 4, and 5 mg/kg without pressure adjustment and at 2 mg/kg after pressure adjustment. Coronary flow with halothane was unchanged from control values except for a decrease at 2.5%. Coronary flow was significantly greater with 3, 4, and 5 mg/kg of morphine than with 1.0 and 1.5% halothane.
本研究旨在确定吗啡和氟烷麻醉对冠状动脉血流量的相对影响。通过将腔静脉血引流至心脏切开储血器并将其回输至主肺动脉，对20只犬建立右心旁路。通过右心室插管测量冠状窦引流。第一组（10只犬）依次给予0.5%、1%、1.5%、2.0%和2.5%的氟烷。第二组（10只犬）静脉注射每千克体重1、2、3、4和5毫克吗啡。在每个麻醉剂量水平测定并重复测量动脉压、冠状窦血流量、心输出量、动脉pH值、PCO₂和PO₂，并与对照值进行比较。在未进行压力调整时，3、4和5毫克/千克剂量的吗啡显著增加冠状动脉血流量，在进行压力调整后，2毫克/千克剂量的吗啡也有此作用。除2.5%剂量时有所下降外，氟烷麻醉时的冠状动脉血流量与对照值无变化。3、4和5毫克/千克剂量的吗啡所导致的冠状动脉血流量显著大于1.0%和1.5%氟烷所导致的冠状动脉血流量。
