Wikström M B, Dahlén G, Kaijser B, Nygren H
Infect Immun. 1984 Apr;44(1):33-7. doi: 10.1128/iai.44.1.33-37.1984.
The ability of Streptococcus pneumoniae to degrade human secretory immunoglobulin A (S-IgA), IgG, and IgM was tested in 102 strains by use of the thin-layer enzyme assay cultivation technique. The strains were isolated from patients with acute phases of otitis media, meningitis, and pneumonia as well as from symptomless carriers. An ability to degrade S-IgA, IgG, and IgM was revealed in 50, 84, and 96 strains, respectively. An IgG- and IgM-degrading ability of S. pneumoniae has not previously been reported. A concurrent degradation of the three immunoglobulins was revealed in 38 strains; degradation of two of them was revealed in 54 strains, and degradation of only one of them was revealed in 9 strains. One strain failed to degrade any of the immunoglobulins. Correlations were not found between the ability of the S. pneumoniae strains to degrade S-IgA, IgG, or IgM and the serotype affiliation or between the ability to degrade IgG or IgM and the origin of strains. However, the ability to degrade S-IgA was evident more often in strains isolated from symptomless carriers and from bronchial secretions of patients with acute pneumonia than it was in strains from patients with acute meningitis or acute otitis media or from the blood of patients with acute pneumonia. These latter findings may indicate a biological significance of S-IgA-degrading ability in bacterial colonization of mucosal surfaces.
采用薄层酶法培养技术，对102株肺炎链球菌降解人分泌型免疫球蛋白A（S-IgA）、IgG和IgM的能力进行了检测。这些菌株分别从患有中耳炎、脑膜炎和肺炎急性期的患者以及无症状携带者中分离得到。结果显示，分别有50株、84株和96株具有降解S-IgA、IgG和IgM的能力。此前尚未有关于肺炎链球菌降解IgG和IgM能力的报道。在38株菌株中发现了三种免疫球蛋白的同时降解；在54株菌株中发现了其中两种的降解；在9株菌株中仅发现了其中一种的降解。有1株菌株未能降解任何一种免疫球蛋白。未发现肺炎链球菌菌株降解S-IgA、IgG或IgM的能力与血清型归属之间，以及降解IgG或IgM的能力与菌株来源之间存在相关性。然而，与从急性脑膜炎患者、急性中耳炎患者或急性肺炎患者血液中分离出的菌株相比，从无症状携带者和急性肺炎患者支气管分泌物中分离出的菌株更常表现出降解S-IgA的能力。后一项发现可能表明S-IgA降解能力在细菌黏膜表面定植中具有生物学意义。
