Geraghty J, Feely M
J Neurosurg. 1984 Apr;60(4):724-6. doi: 10.3171/jns.1984.60.4.0724.
A randomized trial was performed to support the contention that prophylactic antibiotics can reduce the incidence of postoperative neurosurgical wound infections. The regime outlined by Malis was followed. Vancomycin and gentamicin were administered systemically just prior to surgery and streptomycin was added to the irrigating solution. Patients were randomly assigned to two groups: control and treated. The infection rate in the control group was 3.5% and in the treated group 0.5%.
进行了一项随机试验，以支持预防性抗生素可降低神经外科术后伤口感染发生率这一论点。采用了马利斯概述的方案。术前立即全身给予万古霉素和庆大霉素，并在冲洗液中加入链霉素。患者被随机分为两组：对照组和治疗组。对照组的感染率为3.5%，治疗组为0.5%。
