链脲佐菌素诱导的糖尿病雄性大鼠下丘脑-垂体-性腺轴

Hypothalamic-hypophyseal-gonadal axis in the streptozotocin-induced diabetic male rat.

作者信息

Calvo J C, Barañao J L, Tesone M, Charreau E H

出版信息

J Steroid Biochem. 1984 Mar;20(3):769-72. doi: 10.1016/0022-4731(84)90083-9.

Abstract

In the present work it was observed that the diabetic state alters the hypophyseal response to castration, without the expected increase in the LH serum levels, as found in the control rats. On the other hand, the stimulation of the hypophysis with LHRH resulted in a lower response in the case of the diabetic animal. The results presented herein are in good agreement with the finding of a reduction in the number of androgen binding sites and also with a diminished activity of the 5 alpha-reductase in the hypophysis from diabetic animals. The present results indicate an alteration in the hypophyseal gonadotropin production as well as in the overall process of hypophyseal response in experimental diabetes.

摘要

在本研究中观察到，糖尿病状态改变了垂体对去势的反应，与对照大鼠不同，糖尿病大鼠血清促黄体生成素水平并未如预期那样升高。另一方面，用促性腺激素释放激素刺激垂体时，糖尿病动物的反应较低。本文给出的结果与糖尿病动物垂体中雄激素结合位点数量减少以及5α-还原酶活性降低的发现高度一致。目前的结果表明，实验性糖尿病中垂体促性腺激素的产生以及垂体反应的整个过程都发生了改变。