Babichev V N, Peryshkova T A, Adamskaia E I
Probl Endokrinol (Mosk). 1993 Jan-Feb;39(1):42-5.
The hypophyseo-gonadal system of male rats with streptozotocin-induced diabetes was studied. The hypophyseal sensitivity to LH releasing hormone was analyzed in vitro and concentrations of sex hormone nuclear receptors in the adenohypophysis, participating in gonadotropin secretion regulation according to a negative feedback mechanism, measured. Streptozotocin injection reduced blood testosterone concentration and levels of androgen nuclear receptors in the rat hypophysis. Blood LH and FSH levels in the rats with diabetes were virtually the same as in intact animals. In vitro experiments have demonstrated that diabetes development in rats did not influence the level of LH basal secretion by the hypophysis. The maximal response to LH releasing hormone was recorded in the control males in 3 h incubation, whereas the rate of LH secretion in the experimental animals did not differ from the normal one. The authors suggest that changed mechanism of the hypothalamo-hypophyseo-gonadal system regulation in experimental diabetes is related to the hypophyseal disorders, involving reduction of the LH-RH-stimulated gonadotropin release and of the testosterone receptor levels, this resulting in poor reproductive function control according to the negative feedback principle.
对链脲佐菌素诱导的糖尿病雄性大鼠的垂体-性腺系统进行了研究。体外分析了垂体对促黄体生成素释放激素的敏感性，并测量了腺垂体中参与根据负反馈机制调节促性腺激素分泌的性激素核受体浓度。注射链脲佐菌素降低了大鼠垂体中的血液睾酮浓度和雄激素核受体水平。糖尿病大鼠的血液促黄体生成素（LH）和促卵泡生成素（FSH）水平与正常动物基本相同。体外实验表明，大鼠糖尿病的发展并未影响垂体促黄体生成素基础分泌水平。在对照雄性大鼠孵育3小时时记录到对促黄体生成素释放激素的最大反应，而实验动物中促黄体生成素的分泌速率与正常动物无异。作者认为，实验性糖尿病中下丘脑-垂体-性腺系统调节机制的改变与垂体紊乱有关，包括促黄体生成素释放激素刺激的促性腺激素释放减少以及睾酮受体水平降低，这导致根据负反馈原则对生殖功能的控制不佳。
