钙对肾素释放的双相性改变。

Biphasic alteration of renin release by calcium.

作者信息

Hinko A, Franco-Saenz R, Mulrow P J

出版信息

Proc Soc Exp Biol Med. 1984 Apr;175(4):454-7. doi: 10.3181/00379727-175-41820.

Abstract

The effects of calcium reintroduction on renin release were examined. Calcium reintroduction to calcium-deprived rat renal cortical slices caused an initial stimulation of renin release (30-40 min) followed by a period of suppression of release (4.5 hr). With ouabain present the initial stimulation was enhanced but the subsequent fall in release was more pronounced. Our results suggest that although renin release from juxtaglomerular cells can be both stimulated and inhibited by raising intracellular calcium, it is the inhibition of release that is the more persistent effect.

摘要

研究了钙重新引入对肾素释放的影响。向缺钙大鼠肾皮质切片重新引入钙会导致肾素释放最初受到刺激（30 - 40分钟），随后是释放抑制期（4.5小时）。存在哇巴因时，最初的刺激增强，但随后释放的下降更明显。我们的结果表明，虽然升高细胞内钙可刺激和抑制球旁细胞释放肾素，但释放抑制是更持久的效应。