Lalla M, Paimela H, Räsänen V
Scand J Gastroenterol. 1983 May;18(3):397-9. doi: 10.3109/00365528309181613.
Thirty-three duodenal ulcer patients (group A) were examined for gastric acid secretion capacity and serum group I pepsinogens (PG I) under basal conditions. Another group of 36 duodenal ulcer patients (group B), who had undergone proximal gastric vagotomy (PGV) 1 year previously, were similarly examined. Mean basal acid output, mean insulin-stimulated peak acid output, and mean pentagastrin-stimulated peak acid output in the conservatively treated group were 4.5 meq/h, 25.1 meq/h, and 34.4 meq/h, respectively. The corresponding values in the PGV group were 2.5 meq/h, 6.7 meq/h, and 18.5 meq/h. The mean serum PG I concentration in group A was 103.6 ng/ml and in group B 69.9 ng/ml, whereas the mean serum PG I concentration in 34 healthy control subjects was 47.9 ng/ml. The differences in serum PG I concentrations between all three groups were statistically significant (p less than 0.05). An elevated concentration of serum PG I is associated with clinical ulcer disease in unoperated patients, but the wide overlap in the PG I concentration area between duodenal ulcer patients and healthy persons limits the use of PG I determinations in disturbances of gastric acid secretion.
对33例十二指肠溃疡患者（A组）在基础状态下检测胃酸分泌能力和血清I组胃蛋白酶原（PG I）。另一组36例十二指肠溃疡患者（B组），他们在1年前接受了近端胃迷走神经切断术（PGV），同样进行了检测。保守治疗组的基础胃酸分泌量均值、胰岛素刺激后的胃酸分泌峰值均值和五肽胃泌素刺激后的胃酸分泌峰值均值分别为4.5 meq/h、25.1 meq/h和34.4 meq/h。PGV组的相应值分别为2.5 meq/h、6.7 meq/h和18.5 meq/h。A组血清PG I浓度均值为103.6 ng/ml，B组为69.9 ng/ml，而34名健康对照者的血清PG I浓度均值为47.9 ng/ml。三组之间血清PG I浓度的差异具有统计学意义（p小于0.05）。血清PG I浓度升高与未手术患者的临床溃疡病相关，但十二指肠溃疡患者和健康人之间PG I浓度范围存在广泛重叠，限制了PG I测定在胃酸分泌紊乱中的应用。
