Tanaka Y, Mine K, Nakai Y, Mishima N, Nakagawa T
Department of Psychosomatic Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Gut. 1991 Aug;32(8):849-52. doi: 10.1136/gut.32.8.849.
To investigate the relation of the serum group I pepsinogen (PG I) concentration to the location of gastric ulcers and chronicity of peptic ulcers, ulcer patients (n = 322) were compared with endoscopically normal subjects (n = 174). The mean PG I concentration was significantly higher in male control subjects (n = 90) than in female control subjects (n = 84). In male patients with ulcers in the duodenum (n = 69), antrum (n = 34), or angulus portion (the lower third of the body; n = 83), the mean serum PG I concentration was significantly higher than in the control subjects but in patients with an ulcer in the upper body (n = 49) it was similar to control values. Men with active or healing ulcers (n = 149) showed a significantly higher serum PG I concentration than those with scarred lesions (n = 86) when the abnormality was located in either the upper body or in the angulus portion. For female patients (n = 87), the results were similar. These results suggest that serum PG I concentrations reflect the stages of activity of peptic ulcer.
为研究血清Ⅰ型胃蛋白酶原（PGⅠ）浓度与胃溃疡位置及消化性溃疡慢性化的关系，对322例溃疡患者与174例内镜检查正常的受试者进行了比较。男性对照受试者（90例）的平均PGⅠ浓度显著高于女性对照受试者（84例）。十二指肠溃疡男性患者（69例）、胃窦溃疡男性患者（34例）或胃角部溃疡男性患者（胃体下三分之一处；83例）的血清PGⅠ平均浓度显著高于对照受试者，但胃体上部溃疡患者（49例）的血清PGⅠ平均浓度与对照值相似。当溃疡病变位于胃体上部或胃角部时，活动期或愈合期溃疡男性患者（149例）的血清PGⅠ浓度显著高于瘢痕期患者（86例）。女性患者（87例）的结果与之相似。这些结果提示血清PGⅠ浓度反映了消化性溃疡的活动阶段。
