Kuster B, Gruber U F
Schweiz Med Wochenschr. 1984 Mar 10;114(10):322-32.
57 papers dealing with the prevention of postoperative thromboembolic complications have been analyzed. They comprise 28 prospective, randomized, comparative studies using objective diagnostic techniques. 2 X 5000 IU daily of heparin-DHE lowers the incidence of deep vein thrombosis in general surgery, thoracic surgery and gynecology significantly better than 2 X 5000 IU heparin alone. In hip surgery 3 X 5000 IU heparin-DHE is more effective than the same amount of heparin alone. In the entire field of orthopedic surgery, heparin-DHE, in a dosage of 2 X 5000 IU, lowers the incidence of fatal pulmonary emboli just as well as dextran 70. With regard to prevention of deep vein thrombosis in general surgery, there is no statistically significant difference between prevention with 2 X 2500 IU heparin-DHE and 2 X 5000 IU heparin. 2 X 2500 IU heparin-DHE significantly lowers the incidence of bleeding complications in general surgery, as evaluated in double-blind studies and compared to 2 X 5000 IU heparin alone.
对57篇关于预防术后血栓栓塞并发症的论文进行了分析。其中包括28项采用客观诊断技术的前瞻性、随机、对照研究。每日2×5000国际单位的肝素-双氢麦角碱在普外科、胸外科和妇科中预防深静脉血栓形成的发生率，明显优于单纯使用2×5000国际单位肝素。在髋关节手术中，3×5000国际单位的肝素-双氢麦角碱比相同剂量的单纯肝素更有效。在整个骨科手术领域，2×5000国际单位剂量的肝素-双氢麦角碱预防致命性肺栓塞的发生率与右旋糖酐70相同。在普外科预防深静脉血栓形成方面，2×2500国际单位肝素-双氢麦角碱与2×5000国际单位肝素预防效果无统计学显著差异。双盲研究评估显示，与单纯使用2×5000国际单位肝素相比，2×2500国际单位肝素-双氢麦角碱显著降低了普外科出血并发症的发生率。
