Danahy D T, Aronow W S
Am Heart J. 1978 Apr;95(4):474-82. doi: 10.1016/0002-8703(78)90239-9.
To assess atrial and ventricular rate changes after lidocaine injection, 18 atrial flutter patients and 35 atrial fibrillation patients were given intravenous lidocaine, mean dose 100 mg. Continuous electrocardiographic recording for 5 minutes before and at least 10 minutes after lidocaine injection was used to determine rate changes. The atrial flutter rate decreased after lidocaine in 17 of 18 patients (94 per cent), mean maximal decrease 27 beats/minute. The ventricular rate response in atrial flutter was variable but in three patients increased 21, 27, and 47 beats/minute respectively (P less than 0.001). In atrial fibrillation, the mean ventricular rate after rapid lidocaine injection increased six beats/minute (P less than 0.01). In three of 35 atrial fibrillation patients (9 per cent), the ventricular rate increase was greater than 20 beats/minute (P less than 0.001), and in two patients (6 per cent), the ventricular rate increase was associated with potentially serious clinical events. Lidocaine-induced ventricular rate increases are common in atrial flutter and fibrillation, particularly in patients who are also receiving quinidine.
为评估利多卡因注射后心房和心室率的变化，对18例心房扑动患者和35例心房颤动患者静脉注射利多卡因，平均剂量为100mg。在注射利多卡因前5分钟及注射后至少10分钟进行连续心电图记录，以确定心率变化。18例患者中有17例（94%）利多卡因注射后心房扑动率下降，平均最大下降幅度为27次/分钟。心房扑动时心室率反应各异，但有3例患者心室率分别增加了21次/分钟、27次/分钟和47次/分钟（P<0.001）。在心房颤动患者中，快速注射利多卡因后平均心室率增加6次/分钟（P<0.01）。35例心房颤动患者中有3例（9%）心室率增加超过20次/分钟（P<0.001），2例（6%）患者心室率增加与潜在严重临床事件相关。利多卡因引起的心室率增加在心房扑动和心房颤动中很常见，尤其是在同时接受奎尼丁治疗的患者中。
