Reeves J D, Vichinsky E, Addiego J, Lubin B H
Adv Pediatr. 1983;30:281-320.
Iron deficiency is a common problem in otherwise healthy children and in children with systemic disease. We have reviewed the pathophysiology, laboratory diagnosis, and systemic effects of iron deficiency. We have emphasized that routine screening procedures do not efficiently predict those otherwise healthy children who will demonstrate a therapeutic response to iron. Furthermore, in patients with certain systemic diseases the diagnosis of iron deficiency is complicated by the inflammatory process and the response to a therapeutic trial of oral iron is often blunted. Since the potential adverse effects of iron deficiency may be extensive, a therapeutic trial of iron is indicated to establish the diagnosis of iron deficiency if the index of suspicion is high and laboratory results are equivocal.
缺铁是健康儿童以及患有全身性疾病儿童中常见的问题。我们回顾了缺铁的病理生理学、实验室诊断及全身影响。我们强调，常规筛查程序无法有效预测哪些健康儿童会对铁剂治疗产生反应。此外，对于某些全身性疾病患者，缺铁的诊断因炎症过程而变得复杂，口服铁剂治疗试验的反应往往不明显。由于缺铁的潜在不良影响可能广泛存在，如果怀疑指数高且实验室结果不明确，则需进行铁剂治疗试验以确诊缺铁。
