Cracknell S E, Hinchliffe R F, Lilleyman J S
University of Sheffield Department of Paediatrics, Children's Hospital, Western Bank.
J Clin Pathol. 1995 Dec;48(12):1137-8. doi: 10.1136/jcp.48.12.1137.
To determine whether skin puncture blood can be used reliably for CD4 lymphocyte counts, the numbers of the major subsets of lymphocytes were assessed in paired venous and skin puncture blood samples from 22 children and 10 adults. Paired values were highly correlated, with skin puncture values being about 7% higher than venous values for each cell type. Differences were of borderline statistical significance for total lymphocytes and for each subset except CD3+ CD8+ T lymphocytes. Nevertheless, the magnitude of the differences was small and unlikely to be of clinical importance, and it seems that skin puncture samples may be preferable for CD4 counts in children or adults with difficult venous access.
为了确定皮肤穿刺采血是否能可靠地用于CD4淋巴细胞计数，我们对22名儿童和10名成人的配对静脉血和皮肤穿刺血样本中的主要淋巴细胞亚群数量进行了评估。配对值高度相关，每种细胞类型的皮肤穿刺值比静脉值高约7%。除CD3 + CD8 + T淋巴细胞外，总淋巴细胞及各亚群的差异具有临界统计学意义。然而，差异幅度较小，不太可能具有临床重要性，对于静脉穿刺困难的儿童或成人，皮肤穿刺样本似乎更适合用于CD4计数。
