Tandon A P, Smith D R, Ionescu M I
Am Heart J. 1978 May;95(5):595-601. doi: 10.1016/0002-8703(78)90301-0.
Hemodynamic studies were performed in 27 patients at a mean interval of 40.3 (range 24 to 59) months following mitral valve replacement with pericardial xenografts. Six patients had sequential studies, one before operation and two separate investigations at mean intervals of 11.2 and 42.8 months following valve replacement. The results showed significant increase in cardiac index, reduction in mean pulmonary artery and wedge pressures, and decrease in pulmonary vascular resistance both at rest and during exercise, when compared with the preoperative values. The mean diastolic gradient across the pericardial xenografts was 6.4 mm. Hg at rest and 15.3 mm. Hg during exercise. The calculated xenograft surface area was 2.0 and 2.3 cm.2, respectively. The sequential studies established that the maximum hemodynamic improvement was achieved within the first year following valve replacement and that the functional performance of the xenografts was maintained, unaltered, with the passage of time.
对27例使用心包异种移植物进行二尖瓣置换术的患者进行了血流动力学研究，平均随访间隔为40.3个月（范围24至59个月）。6例患者进行了序贯研究，1例在手术前，另外2例在瓣膜置换术后平均间隔11.2个月和42.8个月分别进行了独立研究。结果显示，与术前值相比，静息和运动时心脏指数显著增加，平均肺动脉压和楔压降低，肺血管阻力下降。心包异种移植物静息时平均舒张压差为6.4 mmHg，运动时为15.3 mmHg。计算得出的异种移植物表面积分别为2.0和2.3 cm²。序贯研究表明，瓣膜置换术后第一年内血流动力学改善最大，且随着时间推移，异种移植物的功能性能保持不变。
