催乳素诱导妊娠兔乳腺外植体中的α-乳白蛋白活性。表皮生长因子和糖皮质激素的作用。
Prolactin-induced alpha-lactalbumin activity in mammary explants from pregnant rabbits. A role for epidermal growth factor and glucocorticoids.
作者信息
Sankaran L, Topper Y J
出版信息
Biochem J. 1984 Feb 1;217(3):833-7. doi: 10.1042/bj2170833.
Exogenous prolactin alone can induce alpha-lactalbumin activity in rabbit mammary explants. Under these conditions, exogenous corticosol has no effect. However, low levels of epidermal growth factor (EGF) can markedly inhibit the induction by prolactin, and this inhibitory effect, in turn, can be prevented by cortisol. The steroid can, in fact, convert EGF from a potent inhibitor into an agent which enhances the induction. None of the other growth factors tested inhibits induction of alpha-lactalbumin activity by prolactin, and no other type of steroid tested overcomes the effect of EGF. The results suggest that, under physiological conditions, glucocorticoid may be essential for induction of alpha-lactalbumin activity in the rabbit in order to override the effect of serum EGF.
单独的外源性催乳素可诱导兔乳腺外植体中的α-乳白蛋白活性。在这些条件下，外源性皮质醇没有作用。然而，低水平的表皮生长因子（EGF）可显著抑制催乳素的诱导作用，而这种抑制作用又可被皮质醇阻止。实际上，这种类固醇可将EGF从一种强效抑制剂转变为一种增强诱导作用的因子。所测试的其他生长因子均不抑制催乳素对α-乳白蛋白活性的诱导作用，且所测试的其他类型类固醇均不能克服EGF的作用。结果表明，在生理条件下，糖皮质激素对于兔体内α-乳白蛋白活性的诱导可能至关重要，以便克服血清EGF的作用。
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