Odonkor J M, Rogers M P
Biochem Pharmacol. 1984 Apr 15;33(8):1337-41. doi: 10.1016/0006-2952(84)90189-8.
The role of LPL in reducing the serum triacylglycerol concentration was investigated in rats fed a high sucrose diet containing 0.25% (w/w) ethyl-CPIB. Compared with sucrose-fed controls, drug treatment resulted in a fall in adipose tissue LPL activity and a rise in enzyme activity in thigh and heart muscle. Serum post-heparin lipoprotein lipase activity after a high dose of heparin was lower in ethyl-CPIB-treated rats than controls, but after a low dose of heparin the values were similar. The amount of LPL activator was decreased by the drug. Thus, the low serum triacylglycerol concentration observed in the ethyl-CPIB-treated rats cannot be explained by changes in functional LPL activity. The plasma triacylglycerol-lowering effect of the drug could be explained by the observed decrease in triacylglyerol output by the liver.
在喂食含0.25%（w/w）乙基-CPIB的高蔗糖饮食的大鼠中，研究了脂蛋白脂肪酶（LPL）在降低血清三酰甘油浓度方面的作用。与喂食蔗糖的对照组相比，药物治疗导致脂肪组织LPL活性下降，大腿和心肌中的酶活性升高。高剂量肝素后，乙基-CPIB处理的大鼠血清肝素后脂蛋白脂肪酶活性低于对照组，但低剂量肝素后，数值相似。该药物降低了LPL激活剂的量。因此，在乙基-CPIB处理的大鼠中观察到的低血清三酰甘油浓度不能用功能性LPL活性的变化来解释。该药物的血浆三酰甘油降低作用可以用观察到的肝脏三酰甘油输出减少来解释。
