Beletskaia L V, Beliaev D L, Blandova Z K, Malyshenko A M, Bukhova V P
Nauchnye Doki Vyss Shkoly Biol Nauki. 1984(2):108-12.
With the help of antibodies-containing serum reacting with the thymus reticulum epithelial cells components by immunofluorescence method the thymus parenchimal tissue in mice with functional and pathological involution has been detected electively. In spite of large thymus changes in hairless mice with the mutation of gene hrrhy in 14-th chromosome of B10.R109/Y animals the basal cells antigen in epithelial reticulum has been preserved. It permits to estimate thymus involution level of this organ. Low lymphocyte content in the thymus of C57BL/6 mice is accompanied by total decamouflage of the epithelium. The functional thymus involution of pregnant mice is characterized by the luminescence of large number of epithelial cells, the restoration of organ after the delivery--by their few number. The elective detection of thymus epithelium many serve as additional test for the estimation of functional and pathological involution level.
借助含抗体血清，通过免疫荧光法与胸腺网状上皮细胞成分发生反应，已选择性地检测出功能性和病理性退化小鼠的胸腺实质组织。尽管B10.R109/Y动物第14号染色体上hrrhy基因突变的无毛小鼠胸腺有很大变化，但上皮网状组织中的基底细胞抗原得以保留。这有助于评估该器官的胸腺退化水平。C57BL/6小鼠胸腺中淋巴细胞含量低伴随着上皮细胞的完全消失。怀孕小鼠的功能性胸腺退化表现为大量上皮细胞发光，分娩后器官恢复则表现为上皮细胞数量减少。胸腺上皮的选择性检测可作为评估功能性和病理性退化水平的附加测试。
