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[利用天然抗体检测动物和人类上皮组织中基底细胞抗原的定位]

[Localization of basal cell antigen in the epithelial tissues of animals and humans detected by means of natural antibodies].

作者信息

Beletskaia L V, Beliaev D L, Gnezditskaia E V, Bukhova V P, Mudrenko I Iu

出版信息

Arkh Anat Gistol Embriol. 1985 May;88(5):61-5.

PMID:3896202
Abstract

By means of the immunofluorescent method using rabbit serum that contains natural antibodies against the basal cell antigen of epidermis, the distribution of the antigen has been demonstrated in cells of the basal layer of all types of the stratified epithelium. The reaction is also noted in cytoplasm of the epithelial cells in the thymus and the tracheal mucous membrane. This demonstrates their histogenic affinity to stratified epithelii. The antigen studied is not species-specific, since it is revealed in the stratified epithelium of all species examined (human being, mouse, rat, guinea pig, rabbit). It is possible to use the basal cell antigen as a marker for immunomorphological reveal of epithelial cells in the thymus in the process of its physiological and pathological involution.

摘要

通过使用含有针对表皮基底细胞抗原的天然抗体的兔血清的免疫荧光法,已证明该抗原在所有类型复层上皮的基底层细胞中均有分布。在胸腺和气管黏膜的上皮细胞胞质中也观察到该反应。这表明它们与复层上皮具有组织发生学上的亲和性。所研究的抗原不是种属特异性的,因为在所有被检查的物种(人类、小鼠、大鼠、豚鼠、兔子)的复层上皮中都能发现它。在胸腺生理和病理 involution 过程中,有可能将基底细胞抗原用作免疫形态学揭示胸腺上皮细胞的标志物。 (注:“ involution”这个词在医学语境下不太明确准确意思,原文可能有误,推测可能是“退化”之类的意思,这里按原样翻译)

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[Localization of basal cell antigen in the epithelial tissues of animals and humans detected by means of natural antibodies].[利用天然抗体检测动物和人类上皮组织中基底细胞抗原的定位]
Arkh Anat Gistol Embriol. 1985 May;88(5):61-5.
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