Compagno J, Oertel J E
Am J Clin Pathol. 1978 Mar;69(3):289-98. doi: 10.1093/ajcp/69.1.289.
Thirty-four cases of microcystic adenoma of the pancreas were studied. These benign tumors have traditionally been classified as cystadenomas, but have not been clearly distinguished from those cystic neoplasms of the pancreas that have a significant malignant potential. Microcystic adenomas are benign, usually large (mean diameter 10.8 cm), and are composed of many tiny cysts lined by small cuboidal cells containing glycogen but little or no mucin. The tumor may be found incidentally at autopsy or, more commonly, may manifest as an abdominal mass with some associated local pain or discomfort. There is no sex predilection. The patients are usually elderly, both mean and median ages being 68. A microcystic pattern is apparent both grossly and microscopically. Electron microscopy confirms the presence of intracytoplasmic glycogen and the epithelial character of the cells. Follow-up data (mean 6.4 years), available in all cases, indicate that when these tumors occur in the head of the pancreas, fatalities may result either from complications of radical surgery or from gastrointestinal or biliary obstruction. When the tumors occur in the body or tail of the pancreas, biopsy alone may be sufficient.
对34例胰腺微囊性腺瘤进行了研究。这些良性肿瘤传统上被归类为囊腺瘤，但尚未与具有显著恶性潜能的胰腺囊性肿瘤明确区分开来。微囊性腺瘤是良性的，通常体积较大（平均直径10.8厘米），由许多微小囊肿组成，囊肿内衬有含有糖原但几乎不含或不含粘蛋白的小立方形细胞。肿瘤可能在尸检时偶然发现，或者更常见的是，可能表现为腹部肿块，并伴有一些局部疼痛或不适。无性别倾向。患者通常为老年人，平均年龄和中位年龄均为68岁。微囊性模式在大体和显微镜下均很明显。电子显微镜证实了胞浆内糖原的存在以及细胞的上皮特征。所有病例均有随访数据（平均6.4年），表明当这些肿瘤发生在胰头时，死亡可能由根治性手术的并发症或胃肠道或胆道梗阻导致。当肿瘤发生在胰体或胰尾时，仅活检可能就足够了。
