Tampi Chandralekha, Mullerpatan Prashant, Shah Rajiv, Jagannath Palepu, Zimmermann Arthur
Department of Pathology, Lilavati Hospital and Research Centre, Mumbai, India.
Pancreatology. 2006;6(3):248-53. doi: 10.1159/000092028. Epub 2006 Mar 15.
Microcystic adenoma or serous cystadenoma is an uncommon tumor and accounts for 1-2% of the exocrine neoplasms of the pancreas. Usually unifocal, they present as single, large, well-demarcated multiloculated cystic tumors, ranging in size from 1 to 25 cm. Multifocal variants or diffuse serous cystadenomas are extremely rare. We present 2 cases of which 1 is a diffuse variant affecting the body, tail and part of the neck of the pancreas. In both the patients the tumors were detected incidentally. We highlight on the diffuse variant in view of its rarity and present a review of literature. In this case the entire body and tail of the pancreas was spongy replaced by multicystic lobules and hyalinized fibrocollagenous stroma. The cysts were lined by low cuboidal glycogen containing bland cells. Such a unique presentation wherein the entire body and tail of the pancreas is replaced with multiple cysts is a diffuse presentation of microcystic adenoma and a search through literature revealed only 7 such cases among the 15 cases with multifocal presentation reported.
微囊性腺瘤或浆液性囊腺瘤是一种罕见的肿瘤，占胰腺外分泌肿瘤的1%-2%。通常为单灶性，表现为单个、较大、边界清晰的多房性囊性肿瘤，大小从1厘米至25厘米不等。多灶性变体或弥漫性浆液性囊腺瘤极为罕见。我们报告2例，其中1例为弥漫性变体，累及胰腺体部、尾部及部分颈部。2例患者均为偶然发现肿瘤。鉴于弥漫性变体的罕见性，我们对其进行重点介绍并对文献进行综述。在该病例中，胰腺的整个体部和尾部被多囊性小叶和玻璃样变的纤维胶原性间质呈海绵状替代。囊肿内衬含有糖原的扁平立方上皮细胞，细胞温和。胰腺的整个体部和尾部被多个囊肿替代，这种独特的表现是微囊性腺瘤的弥漫性表现，在已报道的15例多灶性表现病例中，经文献检索仅发现7例此类病例。
