Buchan A M
Cell Tissue Res. 1984;235(3):657-61. doi: 10.1007/BF00226965.
The pancreas from eleven species of snakes representing both advanced and primitive families has been investigated for the presence of eleven regulatory peptides reported to occur in the mammalian endocrine pancreas. Of the eleven peptides studied, insulin, pancreatic glucagon and somatostatin were present in endocrine cells within the islets of all the species investigated. The neuropeptide, vasoactive intestinal polypeptide, was located within nerve terminals innervating the islets in the Boidinae, Colubrinae, Elaphidae and Crotalidae but absent from the Natricinae investigated. No immunoreactivity was demonstrable with the antisera to substance P, met-enkephalin, C-terminal gastrin, bombesin, glicentin and gastric inhibitory polypeptide. Pancreatic polypeptide-like immunoreactivity was demonstrable only in the boid snakes and exclusively stained by a C-terminal specific antiserum.
对代表高等和原始科的11种蛇的胰腺进行了研究，以检测据报道存在于哺乳动物内分泌胰腺中的11种调节肽。在所研究的11种肽中，胰岛素、胰高血糖素和生长抑素存在于所有被研究物种胰岛内的内分泌细胞中。神经肽血管活性肠肽位于蟒科、游蛇科、眼镜蛇科和蝰蛇科中支配胰岛的神经末梢内，但在所研究的水游蛇科中不存在。针对P物质、甲硫脑啡肽、C端胃泌素、蛙皮素、胰高血糖素样肽和胃抑制多肽的抗血清未显示出免疫反应性。胰多肽样免疫反应性仅在蟒科蛇中可检测到，并且仅被C端特异性抗血清染色。
