使用可溶性抗原针对恶性疟原虫无性血液阶段进行免疫接种。
Immunization against Plasmodium falciparum asexual blood stages using soluble antigens.
作者信息
Perrin L H, Loche M, Dedet J P, Roussilhon C, Fandeur T
出版信息
Clin Exp Immunol. 1984 Apr;56(1):67-72.
Abstract
Saimiri sciureus monkeys have been successfully immunized against a human malaria parasite, Plasmodium falciparum, using soluble antigens purified from schizont and merozoite extracts. High levels of antibodies reacting with schizont and merozoite specific polypeptides of 140 and 200 kdaltons were detected in the sera of protected monkeys. The five immunized monkeys survived a challenge infection with 5 X 10(7) parasites inducing a fulminant disease in control monkeys.
摘要
已使用从裂殖体和裂殖子提取物中纯化的可溶性抗原，成功地使松鼠猴对人类疟原虫恶性疟原虫产生免疫。在受保护猴子的血清中检测到与140和200千道尔顿的裂殖体和裂殖子特异性多肽发生反应的高水平抗体。五只免疫的猴子在受到5×10⁷个寄生虫的攻击感染后存活下来，而相同数量的寄生虫会在对照猴子中引发暴发性疾病。
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