Bruckstein A H, Attia A A
Am J Med. 1978 Mar;64(3):519-22. doi: 10.1016/0002-9343(78)90246-2.
Hepatotoxicity associated with intravenous sodium oxacillin therapy is reported in two drug abusers cured of staphylococcal endocarditis. Coincident with the administration of oxacillin, marked increases in hepatic transaminase were observed and liver biopsy showed nonspecific hepatitis. Upon cessation of oxacillin therapy, liver enzyme values returned to(ward) normal. Reports of oxacillin-associated changes in hepatic enzyme levels are reviewed; further observation of oxacillin-associated hepatotoxicity is warranted.
两名治愈葡萄球菌性心内膜炎的药物滥用者报告了与静脉注射苯唑西林钠治疗相关的肝毒性。在使用苯唑西林的同时，观察到肝转氨酶显著升高，肝活检显示为非特异性肝炎。停用苯唑西林治疗后，肝酶值恢复正常。对苯唑西林相关的肝酶水平变化报告进行了综述；有必要对苯唑西林相关的肝毒性进行进一步观察。
