Short-term and long-term timolol maleate effects on corneal sensitivity.

The authors present data concerning the effect of timolol maleate on corneal sensitivity investigated with the Cochet-Bonnet aesthesiometer and with cotton wool wisps. Among 30 subjects with open-angle glaucoma, 15 subjects underwent a short-term trial with timolol maleate 0.50% in one eye, while 15 served in a long-term trial with timolol maleate 0.50% or 0.25% in both eyes. A light reduction in corneal sensitivity, which did not reach statistical significance, was found during timolol treatment. After discussing the possible explanations of this side effect, the authors advise monitoring this parameter during the therapy.