Nagamani M, McDonough P G, Ellegood J O, Mahesh V B
Am J Obstet Gynecol. 1978 Apr 1;130(7):791-4. doi: 10.1016/0002-9378(78)90010-8.
17 alpha-Hdroxyprogesterone levels (17 alpha-OHP) were measured in 70 samples of amniotic fluid and 30 samples of maternal serum obtained at different stages of normal pregnancy and in samples of maternal serum and amniotic fluid from a pregnancy with the fetus affected with congenital adrenal hyperplasia. The mean level of 17 alpha-hydroxyprogesterone in the amniotic fluid from control pregnancies was 133.9 +/- 7.6 ng. per 100 ml. (range, 25.1 to 266.6 ng. per 100 ml). The levels were significantly higher in midpregnancy (157.4 +/- 8.4 ng. per 100 ml.) than in late pregnancy (79.2 +/- 6.8 ng. per 100 ml.) (p less than 0.01). Amniotic fluid 17 alpha-OHP levels in the affected pregnancy were significantly higher than the control levels. Mean maternal 17 alpha-OHP level during early pregnancy and midpregnancy was 259.5 +/- 22 ng. per 100 ml. and there was a two-to three-fold increase after 37 weeks (672.2 +/- 61 ng. per 100 ml.) The maternal 17 alpha-OHP levels in the affected pregnancy were significantly higher than the control levels after 34 weeks, but before 34 weeks, the level was within the range seen in control pregnancies. Measurement of 17 alpha-OHP levels in the amniotic fluid before 24 weeks and maternal serum after 34 weeks can be utilized for the prenatal diagnosis of congenital adrenal hyperplasia.
在正常妊娠不同阶段获取的70份羊水样本和30份母血样本，以及1例患有先天性肾上腺皮质增生症胎儿的母血和羊水样本中，检测了17α-羟孕酮（17α-OHP）水平。正常妊娠羊水样本中17α-羟孕酮的平均水平为每100毫升133.9±7.6纳克（范围为每100毫升25.1至266.6纳克）。孕中期（每100毫升157.4±8.4纳克）的水平显著高于孕晚期（每100毫升79.2±6.8纳克）（p<0.01）。患病妊娠的羊水17α-OHP水平显著高于对照水平。孕早期和孕中期母血17α-OHP的平均水平为每100毫升259.5±22纳克，37周后增加了2至3倍（每100毫升672.2±61纳克）。患病妊娠的母血17α-OHP水平在34周后显著高于对照水平，但在34周前，该水平在正常妊娠的范围内。孕24周前检测羊水17α-OHP水平和孕34周后检测母血17α-OHP水平可用于先天性肾上腺皮质增生症的产前诊断。
