Feldman S C, Kastin A J
Neuroscience. 1984 Feb;11(2):303-17. doi: 10.1016/0306-4522(84)90025-3.
Delta sleep-inducing peptide has been found in the peripheral circulation of animals entering slow-wave, or delta, sleep. An antiserum to this peptide was used to localize immunoreactive-like delta sleep-inducing peptide in the rat brain. The peptide was shown to have a rather widespread distribution. In the forebrain, the majority of these neurons were found to extend in a continuous rostral-caudal band in the ventral one-third of the brain from the primary olfactory cortex to the lateral hypothalamus. Neurons were also present in the basal ganglia, amygdala, septum, and thalamus. In the brainstem, the neurons were widespread and associated with the reticular formation, raphe nuclei, nuclei of the trigeminal complex, several auditory nuclei--nuclei of the lateral lemniscus, cochlear nuclei, and inferior colliculus--, cerebellum, locus ceruleus, periventricular gray, and vagal and hypoglossal nuclei. Immunoreactive fibers were, in general, difficult to demonstrate; they were seen mainly in the vicinity of the third ventricle and near blood vessels. The function of delta sleep-inducing peptide is unknown and its role in sleep is still under investigation. The distribution of delta sleep-inducing peptide in the present study suggests that the peptide is a component of several systems--arousal, locomotion, auditory, visual and sensory--both somatic and vestibular. The widespread distribution of the peptide, the lack of demonstrable immunoreactive fiber tracts, and the presence of these neurons in areas known to contain aminergic and peptidergic neurons, raises the possibility that neurons containing delta sleep-inducing peptide may exert their effect by projecting directly into blood vessels and/or interacting with neurons in their immediate vicinity.
在进入慢波睡眠或δ睡眠的动物外周循环中发现了δ睡眠诱导肽。用针对该肽的抗血清来定位大鼠脑中免疫反应样δ睡眠诱导肽。结果显示该肽分布相当广泛。在前脑，这些神经元中的大多数在从初级嗅觉皮层到外侧下丘脑的脑腹侧三分之一处，呈连续的头 - 尾带延伸。基底神经节、杏仁核、隔区和丘脑也存在神经元。在脑干中，神经元广泛分布，并与网状结构、中缝核、三叉神经复合体的核、几个听觉核团（外侧丘系核、耳蜗核和下丘）、小脑、蓝斑、室周灰质以及迷走神经核和舌下神经核相关。一般来说，免疫反应性纤维很难显示出来；它们主要见于第三脑室附近和血管附近。δ睡眠诱导肽的功能尚不清楚，其在睡眠中的作用仍在研究中。本研究中δ睡眠诱导肽的分布表明，该肽是多个系统（包括躯体和前庭的觉醒、运动、听觉、视觉和感觉系统）的组成部分。该肽分布广泛、缺乏可显示的免疫反应性纤维束，以及这些神经元存在于已知含有胺能和肽能神经元的区域，这增加了一种可能性，即含有δ睡眠诱导肽的神经元可能通过直接投射到血管中和/或与附近的神经元相互作用来发挥其作用。
