Pöldinger W
Psychopathology. 1984;17 Suppl 2:30-6. doi: 10.1159/000284090.
In a double-blind study on 40 outpatients (20 per group) suffering from endogenous and psychogenic depression of the anxious-agitated or inhibited form, trazodone was compared with doxepin to determine their efficacy and safety, and whether a single daily administration was adequate. Increasing doses of trazodone 50-200 mg and doxepin 25-100 mg were given once a day in the evening for a period of 5 weeks. Both drugs were found to be approximately equivalent as far as their antidepressive and anxiolytic effects and safety are concerned. Treatment with trazodone promises less risks according to the clinical experience described in the international literature. Administration once a day provides sufficient efficacy and safety.
在一项针对40名门诊患者（每组20名）的双盲研究中，这些患者患有焦虑激动型或抑制型内源性和心因性抑郁症，将曲唑酮与多塞平进行比较，以确定它们的疗效和安全性，以及每日单次给药是否足够。每晚一次给予递增剂量的曲唑酮50 - 200毫克和多塞平25 - 100毫克，持续5周。就其抗抑郁、抗焦虑作用和安全性而言，发现两种药物大致相当。根据国际文献中描述的临床经验，用曲唑酮治疗风险较小。每日一次给药可提供足够的疗效和安全性。
