Faure J C, Schellenberg D A, Bexter A, Wuerzner H P
Z Ernahrungswiss. 1984 Mar;23(1):41-51. doi: 10.1007/BF02020895.
The predominance of Bifidobacteria in normal breast-fed babies is well established. Even under unfavourable hygienic conditions of delivery and during the breast-feeding period Bifidobacteria develop and colonize the intestinal tract at high concentrations. In the present study we investigated the interaction between Bifidobacterium longum and a pathogenic E. coli strain in the germ-free rat. Sequential counts of the two bacterial strains allowed their proliferation to be followed. Electron microscopic as well as light microscopic examinations of selected intestinal mucosa segments revealed minor morphological changes. Bifidobacterium completely protected the rats against mortality from a consecutive infection with E. coli. Repeated inoculation of Bifidobacteria even decreased and kept down the initial E. coli population. Thus it appears that the germ-free rat is an appropriate model to study the development and interaction of both bacterial species and that the sequence of inoculation is most important.
双歧杆菌在正常母乳喂养婴儿中占优势这一点已得到充分证实。即使在分娩时卫生条件不利以及母乳喂养期间，双歧杆菌也能生长并在肠道中大量定植。在本研究中，我们在无菌大鼠中研究了长双歧杆菌与致病性大肠杆菌菌株之间的相互作用。对这两种细菌菌株进行连续计数，以便追踪它们的增殖情况。对选定的肠黏膜段进行电子显微镜和光学显微镜检查，发现形态变化较小。双歧杆菌能完全保护大鼠免受连续感染大肠杆菌导致的死亡。反复接种双歧杆菌甚至能减少并控制初始大肠杆菌数量。因此，无菌大鼠似乎是研究这两种细菌物种的生长和相互作用的合适模型，而且接种顺序最为重要。
