Smallwood J K, Haselby K A, Paradise R R
Am J Physiol. 1984 May;246(5 Pt 2):H733-8. doi: 10.1152/ajpheart.1984.246.5.H733.
We have developed an ascorbic acid-dilution method for measuring cardiac output which requires minimal blood withdrawal. Ascorbate is injected into a central venous catheter. The indicator-dilution curve is obtained by drawing blood from an arterial catheter through an amperometric cell at 0.96 ml/min for 35 s. The current is measured by a picoammeter . A calibration curve is obtained in 15 s prior to each indicator-dilution curve. An on-line digital computer measures the curve areas and calculates the cardiac output. Cardiac outputs of heparinized dogs anesthetized with pentobarbital and halothane measured by this method (AA) compared closely to cardiac outputs measured by the dye-dilution method (CG) (AA = 0.96 CG + 20 ml/min, r = 0.98). Both the cardiac output and the arterial blood pressure remained stable during replicate measurements of the cardiac output of 1-day-old piglets. This system allows cardiac output determinations of neonatal subjects without excessive blood removal and, with further development, should be practical in human neonates.
我们开发了一种抗坏血酸稀释法来测量心输出量，该方法所需采血量极少。将抗坏血酸盐注入中心静脉导管。通过以0.96毫升/分钟的流速从动脉导管抽血35秒，经过安培计池来获取指示剂稀释曲线。电流由皮安计测量。在每条指示剂稀释曲线之前的15秒内获取校准曲线。一台在线数字计算机测量曲线面积并计算心输出量。用这种方法（AA法）测量的戊巴比妥和氟烷麻醉的肝素化犬的心输出量，与染料稀释法（CG法）测量的心输出量密切相关（AA = 0.96 CG + 20毫升/分钟，r = 0.98）。在对1日龄仔猪的心输出量进行重复测量期间，心输出量和动脉血压均保持稳定。该系统能够在不大量采血的情况下测定新生儿的心输出量，并且随着进一步发展，在人类新生儿中应该会具有实用性。
