Herlitz J, Hjalmarson A, Holmberg S, Swedberg K, Vedin A, Waagstein F, Waldenström A, Wedel H, Wilhelmsen L, Wilhelmsson C
Br Heart J. 1984 May;51(5):539-44. doi: 10.1136/hrt.51.5.539.
In a double blind study of metoprolol in the treatment of suspected acute myocardial infarction 698 patients (study group) received metoprolol and 697 a placebo (control group). Metoprolol was given in an intravenous dose of 15 mg as soon as possible after admission to hospital followed by 50 g by mouth four times a day for two days and thereafter 100 mg twice a day for three months. A placebo was similarly given. Congestive heart failure occurred in a similar percentage of patients in both the study (27%) and the control groups (30%). Its severity was estimated by calculating the total dose of frusemide given during the first four days in hospital. Less frusemide was given to patients treated with metoprolol compared with those given a placebo in the total series. An appreciably lower total dose of frusemide was given to patients included in the trial less than or equal to 12 hours after the onset of pain and treated with metoprolol compared with a placebo, while no difference was seen among patients treated later. The initial heart rate, systolic blood pressure, and infarct site affected the results.
在一项关于美托洛尔治疗疑似急性心肌梗死的双盲研究中，698例患者（研究组）接受了美托洛尔治疗，697例患者（对照组）接受了安慰剂治疗。入院后尽快给予美托洛尔静脉注射剂量15mg，随后口服50mg，每日4次，共2天，此后每日2次，每次100mg，持续3个月。安慰剂的给药方式与之相同。研究组（27%）和对照组（30%）中出现充血性心力衰竭的患者比例相似。通过计算住院头4天给予速尿的总剂量来评估其严重程度。在整个系列中，与接受安慰剂治疗的患者相比，接受美托洛尔治疗的患者给予的速尿较少。与安慰剂相比，在疼痛发作后12小时内或更短时间内接受美托洛尔治疗的试验患者给予的速尿总剂量明显较低，而在疼痛发作后较晚接受治疗的患者之间未观察到差异。初始心率、收缩压和梗死部位影响了结果。
