Tabuchi K, Ohnishi R, Nishimoto A, Isobe T, Okuyama T
Brain Res. 1984 Apr 30;298(2):353-7. doi: 10.1016/0006-8993(84)91436-7.
Both calmodulin and S-100 protein are Ca2+-binding proteins of the EF-hand family. Immunocytochemical study revealed that calmodulin existed mainly in the neurons, whereas S-100 protein was localized primarily in the glial cells of the cerebral and cerebellar cortices of man and monkey. The observed reverse cellular distribution of calmodulin to S-100 protein in primate brain suggests that calmodulin might be replaced in its role as a Ca2+-binding protein by S-100 protein in the glial cells.
钙调蛋白和S-100蛋白都是EF手型家族的钙结合蛋白。免疫细胞化学研究显示，钙调蛋白主要存在于神经元中，而S-100蛋白主要定位于人和猴大脑及小脑皮质的神经胶质细胞中。在灵长类动物大脑中观察到的钙调蛋白与S-100蛋白相反的细胞分布表明，在神经胶质细胞中，S-100蛋白可能会取代钙调蛋白作为钙结合蛋白的作用。
