Reiher H, Fuhrmann K, Noack S, Besch W, Hahn H J
Exp Clin Endocrinol. 1984 Mar;83(1):110-2. doi: 10.1055/s-0029-1210318.
The in vitro insulin secretion of pancreatic slices between the 11th and 15th week of pregnancy of fetuses from non diabetic ( FNDW ) and diabetic women ( FDW ) after incubation in media supplemented with different secretagogues was investigated in order to study the development of diabetic fetopathy during human pregnancy in diabetic women. There was a stimulatory effect on the insulin secretion in FNDW even if glucose alone was used, which became more pronounced if IBMX was added to the incubation medium. The insulin secretion was significantly enhanced in FDW compared to FNDW . This incubation model using fetal pancreatic slices seems to be appropriate for studying the ontogenesis of the human fetal pancreas.
为了研究糖尿病女性孕期糖尿病胎儿病的发展情况，对非糖尿病女性（FNDW）和糖尿病女性（FDW）妊娠第11至15周胎儿的胰腺切片在添加不同促分泌剂的培养基中孵育后的体外胰岛素分泌情况进行了研究。即使仅使用葡萄糖，对FNDW的胰岛素分泌也有刺激作用，若在孵育培养基中添加异丁基甲基黄嘌呤（IBMX），这种作用会更明显。与FNDW相比，FDW的胰岛素分泌显著增强。这种使用胎儿胰腺切片的孵育模型似乎适合研究人类胎儿胰腺的个体发生。
