Hildebrandt R, Ilius A, Lotz U, Schliack V
Exp Clin Endocrinol. 1984 Apr;83(2):168-72. doi: 10.1055/s-0029-1210326.
Eight type I diabetic patients received a subcutaneous injection of 10 IU regular insulin, or--after a one week interval--a suppository containing 75 IU crystalline insulin, the surfactant Brij 58, and the basic mass. In all patients there was a disease in blood glucose (onset after 20 min, maximum effect after 50 min, end of the effect after 90 min), and the plasma IRI level increased. However, the effect was attenuated in relation to the control test employing s.c. administration. The ratio of subcutaneous to rectal doses required to achieve the same effect was between 1:18 and 1:26.
八名I型糖尿病患者接受了皮下注射10国际单位的常规胰岛素，或者——间隔一周后——接受了一种栓剂，该栓剂含有75国际单位的结晶胰岛素、表面活性剂聚山梨醇酯58和基质。所有患者的血糖均出现变化（20分钟后开始起效，50分钟后达到最大效果，90分钟后效果结束），并且血浆胰岛素免疫反应性（IRI）水平升高。然而，与采用皮下给药的对照试验相比，该效果有所减弱。达到相同效果所需的皮下剂量与直肠剂量之比在1:18至1:26之间。
